Raihan ASMA
Bangabandhu Sheikh Mujib Medical University, Bangladesh
Title: Association of Helicobacter pylori and anaemia
Biography
Biography: Raihan ASMA
Abstract
Background: Helicobacter pylori (H. pylori) associated gastritis may cause iron deficiency anaemia. Therefore, this infection should be diagnosed and cured.
Aim: This study is aimed to find out association of H. pylori infection and iron deficiency anaemia.
Methods: Association of H. pylori infection and anaemia was studied in dyspeptic patients. Those who were found to be normal at upper GI endoscopy were included in this study. Rapid urease test was done to detect H. pylori infection. H. pylori positive patients were considered as group A and H. pylori negative as group B. A total of 194 patients (aged 18 to 60 years) of both sexes were included, 134 belonged to group A and 60 to group B. Five ml of blood was collected from each patients for estimation of hemoglobin level, serum ferritin, mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). Iron deficiency anaemia was defined as hemoglobin(Hb) concentration <120 g/L in men and <110 g/L in women, serum ferritin <12 μg/L, mean corpuscular haemoglobin (MCH) <27 pg, and mean corpuscular volume (MCV) <80 fL. Iron deficiency was considered when serum ferritin was <12 μg/L (70).
Results & Conclusions: Serum ferritin was higher in H. pylori negative group than H. pylori positive group. In the multiple regression model H. pylori infection was associated with 28.8% decrease of serum ferritin (95% CI=-4.85 to-9.1); r2=0.271). The mean MCV was found to be 85.45±6.93 (in fL) in group A and 88.73±4.58 ( in fL) group B. The difference was statistically significant (p<0.05). The mean MCH was significantly lower in group A than group B. In male patients, the mean Hb% was lower than group B and the difference was statistically significant (p<0.05). In female patients mean Hb% of both groups were almost similar. So it appears that H. pylori infection is associated with iron deficiency anaemia.