Siddique Abu Raihan
Sheikh Sayera Khatun Medical college, Bangladesh
Title: Comparison of efficacy of four different Helicobacter pylori eradication regimens in peptic ulcer disease patients at a Medical University Hospital
Biography
Biography: Siddique Abu Raihan
Abstract
In the study 63 H. pylori positive patients with peptic ulcer disease were randomized for eradication therapy for H. pylori for two weeks. Four regimens were used: ECA consisting of Esemoprazole (20 mg bid), Clarithromycin (500 mg bid) and Amoxicillin (1 gm bid), EAL- consisting of Esemoprazole (20mg bid), Amoxicillin (1gm bid), Levofloxaxin (500 mg once daily), EAT consisting of Esemoprazole (20mg bid), Amoxicillin (1gm bid), Tetracycline (500 mg bid) and ETL consisting of Esemoprazole (20 mg bid), Tetracycline (500mg bid) and Levofloxaxin (500 mg once daily). Out of 63 patients 13 dropped out. Six weeks after completion of therapy upper GI endoscopy was repeated to see endoscopic improvement and RUT (rapid urease test) was carried out. Conclusive result was obtained in 40 cases in RUT. Eradication therapy showed no statistically significant difference in different regimens
(p>0.05). Endoscopic improvement occurred in 33% to 71% patients in different regimens. Thirty six patients were found to be RUT negative and 4 were found to be RUT positive. Negativity rate ranged from 83% to 100% in different regimens. This result appears to be acceptable, good and even excellent with ETL.