Bangabandhu Sheikh Mujib Medical University, Bangladesh
Title: Genotype pattern of H. pylori in gastritis and peptic ulcer disease in relation to normal endoscopic findings
Biography: A S M A Raihan
Genotype pattern of H. pylori (Helicobacter pylori) in gastritis and peptic ulcer disease in relation to normal endoscopic findings was studied in 206 H. pylori positive dyspeptic patients (male 128, female 78). H. pylori were diagnosed by RUT (rapid urease test), culture and PCR (polymerase chain reaction). H. pylori positive was considered if any one of the test was positive. Multiplex PCR assay was done directly from biopsy specimens for genotyping. CagA and Vac A alleles were studied. CagA positive and CagA negative in three groups are shown in table 1. CagA gene was found to be significantly more frequent in gastritis and peptic ulcer patients as compared with patients with normal upper GI tract at endoscopy. Association of vac A alleles with gastritis and peptic ulcer was seen as shown in table 2.