Nikiforova Ya.V
National Academy of Medical Sciences of Ukraine, Ukraine
Title: Possibilities of increasing the effectiveness of anti-helicobacter therapy regimens in Ukraine
Biography
Biography: Nikiforova Ya.V
Abstract
The goal is to evaluate the effectiveness of various Anti-Helicobacter therapy (AHBT) regimens in Ukraine in order to select the most optimal treatment tactics.
Object of Study and Methods:
624 patients were examined, with an average age of (50.89 ± 14.17) years. Female (338, 54.1%), Male (286, 45.9%). The most common nosology was chronic atrophic gastritis associated with Helicobacter pylori (ÐÐ ) (501, 78.9%). Non-Investigated Dyspepsia (1, 0.2%), Functional Dyspepsia (2, 0.3%), Duodenal Ulcer (117, 18.4%), Gastric Ulcer (14, 2.2%). Most patients (449, 73.6%) did not receive primary therapy. Patients received different anti-Helicobacter therapy regimens: Dual (2, 0.3%), Triple (332, 52.2%), Quadruple (292, 45.9%), Sequential (0, 0.0%), Hybrid (0, 0.0%), Pylera (single capsule bismuth) (0, 0.0%), Other (10, 1.6%).
Results and discussion.
The most effective eradication scheme is Quadruple with the addition of Bismuth salts of tripotassium dicitrate (BTD) lasting 14 days (92.0%), as well as schemes with the inclusion of probiotics during AHBT with prolonged administration up to 4 weeks after the end of therapy (eradication efficiency is 90.6%). The effectiveness of Quadruple depending on the proton pump inhibitor (PPI) used was: Pantoprazole (92.0%), Esomeprazole (90.0%), Rabeprazole (89.9%), Omeprazole (78.6%) in therapeutic doses.
Conclusions:
Ways to increase the effectiveness of AHTB in Ukraine: adding BTC to therapy and duration of therapy for at least 10-14 days, using high doses of PPIs - Ð antoprazole, adding probiotics to treatment regimens.