Dustov Abdusamad is of the age 64 years from Bangladesh. He is working as Head of the Department of Virology in the Institute of Gastroenterology of Republic of Tajikistan. He is greatly interested in research works on Viruses. He participated in many international conferences. He has more than 20 publications.
Chronic HBV and/or HCV infection can progress to liver cirrhosis and hepatocellular carcinoma (HCC) [1-4]. Among 124 hepatitis patients, 84 (67.7%) were assigned into chronic hepatitis (group 1) and 40 (32.2%) into liver cirrhosis/HCC(group 2). There was no significant difference in age between both groups. The HCV was positive in only 4 of the 15 cases, suggesting that HCV RNA was degraded in these samples, while remaining 11 cases had resolved acute HCV infection. HCV infection was found to be high in both groups (group 1 = 47.6% and group 2 = 42.5%). HCV RNA was detected in 91% of cases (100% in group 1 and 70.5% in group 2). Anti-HBc was found to be high in both groups (94% and 87.5%, respectively). Although Seroprevalence of anti-HBs was very low (12.1%) in the studied population but significantly high in group 1 (16.6%) than group 2 (P = 0.0356).. The Seroprevalence of HBsAg was equally high in both groups, that is, group 1 = 40.4% and group 2 = 42.5%, whereas DNA positivity was 70.5% and 76.4%, respectively. Overall anti-HDV Seroprevalence was 23.5%, 12 out of 51 HBsAg positive cases, relatively higher in group 2 (35.2%) compared to group 1 (17.6%) P = 0.1990. HDV viremia was detected in 83.3% of cases (100% in group 1 and 66.6% in group 2). HCV genotyping was determined as HCV genotype 2c (HCV/2c) in E1 region. A total of 7.6% of cases were un-typeable by one of either method. Overall, HCV/1b was a predominant genotype (84.6%) in Tajikistan, followed by HCV/3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV genotype D (HBV/D) was the predominant genotype (94.1%) in both groups, that is, group 1 = 97% and group 2 = 88.2%, followed by genotype A (2.9% and 11.7%, respectively). HBV genotypes were determined in 45 (88%) of 51 HBsAg-positive. The full genome analysis revealed that of the four HBV/D strains, two belonged to sub genotype D1, and the remaining two to sub genotype D2. All three HBV/A strains in this study were belonged to sub genotype Ae. The results of the phylogenetic genotyping were all concordant with EIA-genotyping results
Rami George Maalouf is graduated from Holy Spirit University of Kaslik in 2018. Now he is in PGY 1 Gastroenterology. He is very much interested on IBD research works and has publications on IBD researches. Currently he is working on IBD.
Background: Gastric acid inhibitors may decrease vitamin B12 absorption and thus lead to vitamin B12 deficiency. PPIs(Proton pump inhibitors) are often overused in the Lebanese population. Objectives: The objective of this study is to evaluate the relationship between the use of proton pump inhibitors and vitamin B12 deficiency in a Lebanese population. Methods: A retrospective case-control study based on a sample of 210 outpatients from the Lebanese community was performed. We compared 70 patients who were originally diagnosed with vitamin B12 deficiency between May 2016 and May 2017 with 140 patients without vitamin B12 deficiency. Results: After comparing the two groups, cases and controls, that were matched by age and gender, we found that there was a significant P value of 0.0001, indicating that the number of long-term PPI users (equal or more than 2 years) have a higher proportion among the cases (vitamin B12 deficiency) than among the controls (no vitamin B12 deficiency). In addition, we found that the P value is more significant in the “only women” group (P=0.004), but P values concerning age groups are not coherent. Conclusions: We conclude that a significant association between long-term proton pump inhibitors use and vitamin B12 deficiency in a Lebanese population exists, which is stronger among women but unclear concerning the age groups.